MOM CHARGED FOR GIVING SICK CHILD MARIJUANA

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Cannabis And Cancer by huffingtonpost

 

cannabis cure cancer plant oil thc cbdWith ever-increasing costs of conventional healthcare, and continuing issues with insurance coverage, alternative medicine is growing in popularity. Inasmuch as it is still officially denigrated, cannabis is about as “alternative” as it gets.

This, despite no shortage of historic references to cannabis, or its extract marijuana (prepared from the dried and crushed flowers and leaves of the plant) as to its medicinal effects. Chinese Emperors Fu Hsi (2900 BC) and Shen Nung (2700 BC) are said to have touted its healing effects. Some authorities claim that the anointing oil in Exodus 30:22-25 contained cannabis, and that “cane” is a mistranslation from the original Hebrew (1450 BC). Getting more into modern times, marijuana was added to the US Pharmacopeia in 1850, and its use is indicated for an astonishingly diverse litany of illnesses.

According to this PDQ Review from the National Cancer Institute, and referring to this illustration, cannabis may lessen the progression of cancer cells. It also alleviates pain, lowers inflammation and decreases anxiety.

An oft-cited study from 1996 on mice and rats suggested that cannabinoids (any of various chemical constituents of cannabis) may have a protective effect against the development of hepatic adenoma tumors and hepatocellular carcinoma. The study also noted decreased incidences of benign tumors in other organs (mammary gland, uterus, pituitary, testis, and pancreas).

A review article (2006)—appearing in the British Journal of Pharmacology—entitled “Cannabinoids and cancer: pros and cons of an antitumour strategy” listed few cons, and displayed a largely positive picture:

Cannabinoids have the advantage of being well tolerated in animal studies and they do not present the generalized toxic effects of most conventional chemotherapeutic agents. Cannabinoids selectively affect tumor cells more than their nontransformed counterparts that might even be protected from cell death. Even if further in vivo research is required to clarify [their] action in cancer and especially to test their effectiveness in patients, the cannabinoid system represents a promising target for cancer treatment.

As to the palliative aspects of Cannabis during cancer treatment, the official version of things is… curious. According to a recent document from PubMed Health

Several controlled clinical trials have been performed, and meta-analyses of these support a beneficial effect of cannabinoids (dronabinol and nabilone) on chemotherapy-induced nausea and vomiting (N/V) compared with placebo. Both dronabinol and nabilone are approved by the U.S. Food and Drug Administration for the prevention or treatment of chemotherapy-induced N/V in cancer patients.

fullextractcannabisoilThus, the FDA has approved two drugs, which are nothing more than synthetic versions of chemicals in cannabis. In addition to the anti-nausea/vomiting properties, dronabinol is used to treat loss of appetite in people with AIDS. Analgesic properties are also claimed for both drugs.

However, owing to the bizarre stigmatization of cannabis, and the difficulty in obtaining proper clearance to study it in clinical settings, there is only a limited amount of published research available on the palliative properties of the source plant itself. Yet, anecdotal evidence of its effects is widely disseminated.

The website Surviving Mesothelioma offers inspiring stories of several people who have survived this rare form of cancer. The disease develops from cells of the mesothelium, a membrane that protects the body’s major internal organs and allows them freedom of movement (for example, lung contractions). The five-year survival rate is poor—at nine percent or less—and has not improved much over the last 30 years.

The chronicle of Andy Ashcraft is quite compelling. He was diagnosed with late stage pleural mesothelioma in 2010, and given three months to a year. Far from being resigned to this fate, Andy and his wife investigated and embarked on alternative therapies, including cannabis oil. Six years later, alive and well, he really has beaten the odds, and is another one of those “anecdotal” cases of an alternative approach success.

The stigmatization of cannabis is fading, but it won’t come easy. After all, lining up on the other side are Big Pharma and Big Law Enforcement. But if a therapy works, and it costs less…

Michael D. Shaw

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Active Ingredient in Cannabis Kills Cancer Cells in Brain

LabNew research out of Spain suggests that THC — the active ingredient in marijuana — appears to prompt the death of brain cancer cells.

The finding is based on work with mice designed to carry human cancer tumors, as well as from an analysis of THC’s impact on tumor cells extracted from two patients coping with a highly aggressive form of brain cancer.

Explaining that the introduction of THC into the brain triggers a cellular self-digestion process known as “autophagy,” study co-author Guillermo Velasco said his team has isolated the specific pathway by which this process unfolds, and noted that it appears “to kill cancer cells, while it does not affect normal cells.”

Velasco is with the department of biochemistry and molecular biology in the School of Biology at Complutense University in Madrid. The findings were published in the April issue of The Journal of Clinical Investigation.

The Spanish researchers focused on two patients suffering from “recurrent glioblastoma multiforme,” a fast-moving form of brain cancer. Both patients had been enrolled in a clinical trial designed to test THC’s potential as a cancer therapy.

Using electron microscopes to analyze brain tissue taken both before and after a 26- to 30-day THC treatment regimen, the researchers found that THC eliminated cancer cells while it left healthy cells intact.

The team also was able, in what it described as a “novel” discovery, to track the signaling route by which this process was activated.

These findings were replicated in work with mice, which had been “engineered” to carry three different types of human cancer tumor grafts.

“These results may help to design new cancer therapies based on the use of medicines containing the active principle of marijuana and/or in the activation of autophagy,” Velasco said.

Outside experts suggested that more research is needed before advocating marijuana as a medicinal intervention for brain cancer.

Dr. John S. Yu, co-director of the Comprehensive Brain Tumor Program in the Maxine Dunitz Neurosurgical Institute at Cedars-Sinai Medical Center in Los Angeles, said the findings were “not surprising.”

“There have been previous reports to this effect as well,” he said. “So this is yet another indication that THC has an anti-cancer effect, which means it’s certainly worth further study. But it does not suggest that one should jump at marijuana for a potential cure for cancer, and one should not urge anyone to start smoking pot right away as a means of curing their own cancer.”

But that’s exactly what many brain cancer patients have been doing, said Dr. Paul Graham Fisher, the Beirne Family director of Neuro-Oncology at Stanford University.

“In fact, 40 percent of brain tumor patients in the U.S. are already using alternative treatments, ranging from herbals to vitamins to marijuana,” he said. “But that actually points out a cautionary tale here, which is that many brain cancer patients are already rolling a joint to treat themselves, but we’re not really seeing brain tumors suddenly going away as a result, which we clearly would’ve noticed if it had that effect. So we need to be open-minded. But this suggests that the promise of THC might be a little over-hoped, and certainly requires further investigation before telling people to go out and roll a joint.”

By Alan Mozes

HealthDay Reporter
April 2

More information

For additional details on the risks and benefits of marijuana use as it relates to cancer, visit the National Cancer Institute or the American Cancer Society.

SOURCES: Guillermo Velasco, Ph.D., department of biochemistry and molecular biology, School of Biology, Complutense University, Madrid; John S. Yu, M.D., co-director, Comprehensive Brain Tumor Program, Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles; Paul Graham Fisher, M.D., associate professor, neurology, pediatrics, and neurosurgery and human biology and the Beirne Family Director of Neuro-Oncology, Stanford University; April 2009, The Journal of Clinical Investigation

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University of Reading – Cannabis discovery could lead to new epilepsy treatments

Scientists at the University of Reading have demonstrated for the first time that a previously unstudied chemical in cannabis could lead to more effective treatments for people with epilepsy.

Read more: http://www.reading.ac.uk/news-and-events/releases/PR464765.aspx

The Data is Very Strong: Marijuana Plant Extract Stops Cancers From Spreading

The data is very strong and there’s no toxicity associated with A compound found in cannabis could halt the spread of many forms of aggressive cancer, scientists say.



The first research to show marijuana’s anti-tumor properties was presented at the American Association for Cancer Research meeting in Los Angeles in 2007 demonstrating that THC may activate biological pathways that halt cancer cell division or block development of blood vessels that feed tumors. It then became a target of synthetic research into THC for drugs such as ImClone System Inc.’s Erbitux and Amgen Inc.’s Vectibix.

Researchers have now found that the compound, called cannabidiol, had the ability to ‘switch off’ the gene responsible for metastasis in an aggressive form of breast cancer. Importantly, this substance does not produce the psychoactive properties of the cannabis plant.

The team from the California Pacific Medical Center, in San Francisco, first spotted its potential five years ago, after it stopped the proliferation of human breast cancer cells in the lab.

Last year they published a study that found a similar effect in mice. Now they say they are on the verge of publishing further animal study results that expand these results further…

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